Effect of Endocrine Disruptors on the Male Reproductive System: Comparative Study on Effects of Carbofuran and Imidacloprid on Andrological and Biochemical Parameters in Male Rabbits

Chemicals causing Endocrine disruptors are present in the environment and they have anti-androgenic and/or estrogen likes properties that cause deleterious effect on the male reproductive system resulting in infertility and erectile dysfunction (ED). These estrogen like or anti-androgenic chemicals are called endocrine disruptors because they either intimate the structure of natural hormones, causes the inhibition of action of the hormones or produces changes in the normal hormonal regulation of the endocrine system. Many pesticides with endocrine disrupting properties are known to adversely damage reproductive competence of the male and females. Pesticides are considered as a highly diverse group of compounds and they present one of the most important groups of chemical stressors in the environment. Majority of human population is exposed to these contaminants in the general environment or either in their working places. Chemical insecticides used today are neurotoxicants and they act by destroying the nervous system of the target organisms. Pesticides being endocrine disruptors affect the male reproductive system by disturbing endocronologic homeostasis.