Biomarkers for Psychiatric Disorders 2009 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: Preface -- 1. Blood and Brain Gene Expression in Major Psychiatric Disorders: A Search for Biomarkers / Gursharan Chana, Stephen J. Glatt, Ian P. Everall, Ming T. Tsuang -- 2. Biomarkers in Schizophrenia / Laura A. Feldcamp, Albert H. C. Wong -- 3. Proteomic Strategies for Biomarker Discovery: From Differential Expression to Isoforms to Pathways / Christoph W. Turck, Claudia Ditzen, Eser Sayan-Ayata -- 4. Schizophrenia Biomarkers: A Means to Advance Disease Understanding, Diagnosis and Treatment / Emanuel Schwarz, Sabine Bahn -- 5. RNA Biomarkers in Schizophrenia / Daniel Martins-de-Souza, Emmanuel Dias-Neto -- 6. Metabolomics: A Global Biochemical Approach to the Discovery of Biomarkers for Psychiatric Disorders / Rima Kaddurah-Daouk, Jair C. Soares, Marlon P. Quinones -- 7. Animal Models for Schizophrenia: A Brief Overview / Miyako Furuta, Hiroshi Kunugi -- 8. Synaptoproteomics of Existing and New Animal Models of Depression / Alessandra Mallei, Roberto Giambelli, Aram El Khoury, Susanne H. M. Gruber, Laura Musazzi, Valentina S. Barbiero, Daniela Tardito, Barbara Vollmayr, Peter Gass, Aleksander A. Mathe, Giorgio Racagni, Maurizio Popoli -- 9. Animal Models for Anxiety Disorders / Su Guo -- 10. Animal Models of Affective Behaviors and Drug Addiction / Eva Drews, Astrid Becker, Andras Bilkei-Gorzo, Andreas Zimmer -- 11. Neuroimaging Biomarkers in Schizophrenia / Heike Tost, Andreas Meyer-Lindenberg -- 12. Sleep EEG Provides Biomarkers in Depression / Mayumi Kimura, Axel Steiger -- 13. Strategies to Identify Biomarkers for Depression / Marcelo Paez-Pereda, Markus Panhuysen -- 14. Pharmacogenetics of Antidepressant Response / Alessandro Serretti, Antonio Drago, Michael N. Liebman -- 15. Perspectives for an Integrated Biomarker Approach to Drug Discovery and Development / Irina Antonijevic, Roman Artymyshyn, Carlos Forray, Sylvia Rabacchi, Kelli Smith, Chad Swanson, Joseph Tamm, Wiktor Mazin, Christophe Gerald -- 16. Hunting for Peripheral Biomarkers to Support Drug Development in Psychiatry / Enrico Domenici, Pierandrea Muglia, Emilio Merlo-Pich -- 17. Biomarkers for the Development of Antidepressant and Anxiolytic Drugs / Marcus Ising, Florian Holsboer -- 18. DNA Biomarkers for Pharmacogenomics and Personalized Medicine / John Raelson, Abdelmajid Belouchi -- 19. Biological Modeling in the Discovery and Validation of Cognitive Dysfunctions Biomarkers / Francois Iris -- Index. Jacket Description/Back: Biological markers, as physiological indicators of disease, hold immense promise for diagnostics and clinical drug trials. While for other complex disorders like diabetes and heart disease a limited number of markers are at hand, there are currently no biomarkers available for psychiatric disorders. Here diagnostic tools are restricted to the evaluation of behavioral and clinical phenotypes, a severe limitation for any scientific study. As in any other disease area a major goal is therefore the identification of markers that can categorize subsets of patients in a consistent manner. This will allow a more precise definition of psychiatric disorders and in turn facilitate investigations of the pathophysiology and enhance the ability for patient treatment. Biomarkers for Psychiatric Disorders provides discovery strategies from scientists in academia and pharma and biotech industries. By addressing the various potential uses of psychiatric biomarkers, this edited volume will interest psychiatrists, neuroscientists, and biomedical scientists working in molecular medicine, disease diagnostics, and drug development. Christoph W. Turck is head of the Proteomics and Biomarkers branch at the Max Planck Institute of Psychiatry and holds faculty appointments in the Department of Biochemistry at Ludwig Maximilians University Munich and the International Max Planck Research School for Molecular and Cellular Life Sciences. Publisher Marketing: This edited volume will not only address the area of affective disorders but also other brain disorders that are neurological in nature, including multiple sclerosis and alzheimer disease.